Publications by authors named "Frank-Rainer Klefisch"
Article Synopsis
- Fluconazole-resistant Candida parapsilosis is a growing concern in healthcare settings, leading to outbreaks similar to those caused by Candida auris, with a notable outbreak documented in Berlin from late 2018 through 2022.
- A retrospective study employed whole-genome sequencing (WGS) to analyze samples from various healthcare facilities to track the spread and resistance patterns of this pathogen.
- The research aimed to create a reliable multi-locus sequence typing (MLST) system to better understand and monitor the outbreak, using patient records and genomic data to analyze transmission dynamics.
Background: Mycobacterium chelonae is a rare cause of infective endocarditis that is difficult to diagnose and treat. After we found M chelonae in a series of patients, we aimed to investigate its role in cardiovascular prosthesis dysfunction and contamination of bioprostheses as a possible cause of infection.
Methods: In this collaborative microbiological study, we report on nine patients treated in three cardiovascular surgical departments in Germany, who were found to have M chelonae infection after receiving BioIntegral bioprostheses.
Carbapenem-resistant (CRE) cause health care-associated infections worldwide, and they are of severe concern due to limited treatment options. We report an outbreak of KPC-2-producing CRE that was caused by horizontal transmission of a promiscuous plasmid across different genera of bacteria and hospitals in Germany. Eleven isolates (8 , 2 , and 1 ) were obtained from seven critically ill patients during the six months of the outbreak in 2016.
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