Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.

 To provide evidence to support updated guidelines for the management of pregnant women with hereditary thrombophilia in order to reduce the risk of a first venous thromboembolism (VTE) in pregnancy. Systematic review and bayesian meta-analysis. Embase, Medline, Web of Science, Cochrane Library, and Google Scholar from inception through 14 November 2016.

Screening for coagulation disorders in patients with ischemic stroke.

The role of coagulation disorders in the pathogenesis of (recurrent) ischemic stroke is uncertain. Therefore, the clinical utility of screening patients with ischemic stroke for these conditions and the therapeutic implications of a detected coagulation disorder in a patient who experienced ischemic stroke are uncertain. We reviewed the currently available data on the relationship between various inherited and acquired coagulation abnormalities (factor V Leiden and prothrombin G20210A mutations, deficiencies of protein C, protein S and anti-thrombin, hyperhomocysteinemia, the antiphospholipid syndrome and increased levels of fibrinogen) and ischemic stroke.

Using heparin therapy to reverse protein-losing enteropathy in a patient with CDG-Ib.

Background: A 22-year-old female presented with edema, diarrhea, hypoalbuminemia and pancytopenia. She had previously been diagnosed with congenital disorder of glycosylation type Ib, and had a history of congenital hepatic fibrosis, portal hypertension and esophageal varices. In the past she had refused mannose therapy because of associated diarrhea and abdominal pain.

Advances in the detection of pulmonary embolism.

Background: Diagnosing or excluding pulmonary embolism is a complex challenge. Many diagnostic instruments can be used in patients with clinically suspected pulmonary embolism nowadays, all with their own (dis-)advantages. Methods/objectives: In this review, these (dis-)advantages are discussed for the following diagnostic instruments: clinical probability assessment, D-dimer concentration, the combination of clinical probability assessment and D-dimer concentration, bilateral compression ultrasonography, ventilation/perfusion scintigraphy, computerized tomographic pulmonary angiography, pulmonary angiography and magnetic resonance pulmonary angiography.