Publications by authors named "Frank Tranghese"
Article Synopsis
- Pediatric brain cancer medulloblastoma (MB) has various subgroups, with Group 3 facing the highest relapse rates and a low survival rate of 20% following standard treatment, prompting exploration of new therapies targeting GABRA5 and its receptor.
- Research shows that Group 3 MB tumors have a high presence of functional GABA type A receptors (GABAR), which play a role in regulating cell viability and chloride ion flow.
- A promising benzodiazepine derivative, 'KRM-II-08', binds to α5-GABAR and induces cell death in Group 3 cells by disrupting ion balance, positioning GABRA5 as both a potential diagnostic marker and therapeutic target for this aggressive subgroup.
Medulloblastoma is the most common childhood malignant brain tumor. The most lethal medulloblastoma subtype exhibits a high expression of the GABAA receptor α5 subunit gene and MYC amplification. New benzodiazepines have been synthesized to function as α5-GABAA receptor ligands.
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