Publications by authors named "Frank Qian"
• Serial stenoses with AS and HCM can pose diagnostic challenges with echocardiography. • Doppler assessment of AS in this situation can overestimate gradients and severity. • Consider TEE and invasive hemodynamics when diagnostic uncertainty remains.
View Article and Find Full Text PDFAims: To assess whether better cardiovascular health is associated with a lower long-term risk of CVD in women with a history of adverse pregnancy outcomes (APOs).
Methods: Using data from the UK Biobank prospective cohort, we included 2,263 participants with prior APOs and 107,260 participants without prior APOs. Life's Essential 8 (LE8) score was assessed at baseline.
Aims/hypothesis: Existing evidence on the relationship between intake of monounsaturated fatty acids (MUFAs) and type 2 diabetes is conflicting. Few studies have examined whether MUFAs from plant or animal sources (MUFA-Ps and MUFA-As, respectively) exhibit differential associations with type 2 diabetes. We examined associations of intakes of total MUFAs, MUFA-Ps and MUFA-As with type 2 diabetes risk.
View Article and Find Full Text PDFRisk prediction for health outcomes in type 2 diabetes: utility of a polysocial risk score?
Lancet Healthy Longev
January 2025
Objective: Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore the relationship between plasma proteomics and PAD in individuals with T2D, and assess whether proteomics could refine PAD risk prediction.
Research Design And Methods: This cohort study included 1,859 individuals with T2D from the UK Biobank.
Background: Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D and marine omega-3 fatty acids (n-3 FA) may improve insulin resistance. We sought to examine the association between baseline levels of insulin, C-peptide, HbA1c, and a novel insulin resistance score (IRS) with incident cardiometabolic diseases, and whether randomized vitamin D or n-3 FA modify these associations.
View Article and Find Full Text PDFBackground: Vitamin D supplementation may prevent acute respiratory infections (ARIs). This study aimed to identify the optimal methods of vitamin D supplementation.
Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.
Article Synopsis
- * Clinical trials have demonstrated PFA's effectiveness in isolating pulmonary veins in patients with both paroxysmal and persistent atrial fibrillation, making it a quick and straightforward method that reduces the risk of iatrogenic (treatment-related) injuries.
- * The paper reviews the mechanisms, benefits, and drawbacks of PFA, highlighting how adjustments in ablation parameters can impact treatment outcomes and suggesting future research directions.
Background: Early identification of impending in-hospital cardiac arrest (IHCA) improves clinical outcomes but remains elusive for practicing clinicians.
Objective: We aimed to develop a multimodal machine learning algorithm based on ensemble techniques to predict the occurrence of IHCA.
Methods: Our model was developed by the Multiparameter Intelligent Monitoring of Intensive Care (MIMIC)-IV database and validated in the Electronic Intensive Care Unit Collaborative Research Database (eICU-CRD).
Article Synopsis
- The study aimed to assess how fish oil supplementation and plasma omega-3 fatty acids relate to risks of complications in people with type 2 diabetes.
- Over a 13.2-year period, it was found that participants taking fish oil had significantly lower risks for both macrovascular and microvascular complications compared to those who did not.
- Higher levels of docosahexaenoic acid (DHA) specifically showed strong protective effects, and metabolism-related biomarkers played a crucial role in explaining these beneficial associations.
Aims: To examine the association of Life's Essential 8 (LE8) with the risk of recurrent cardiovascular events among patients with CHD.
Methods: This prospective cohort study included 11,997 patients with CHD from the UK Biobank. The LE8 score was generated using five lifestyle factors (diet, body mass index, physical activity, smoking, and sleep) and three biological factors (blood lipids, blood glucose, and blood pressure).
Article Synopsis
- * In contrast, research using Mendelian randomization and randomized controlled trials suggests that increasing vitamin D levels may not significantly reduce these risks.
- * Future studies should focus on diverse groups with low vitamin D to explore how maintaining sufficient levels can help prevent major chronic diseases.
Background: Optimal blood pressure (BP) levels to reduce the long-term risk of cognitive decline remains controversial. We aimed to investigate the association between BP and anti-hypertensive treatment status with cognitive decline in older adults.
Methods: This study used data from the China Health and Retirement Longitudinal Study.
Background: The relationship between multimorbidity (i.e. ≥ 2 chronic conditions) and incontinence (i.
View Article and Find Full Text PDFObjective: To prospectively evaluate the association between modifiable lifestyle factors and peripheral artery disease (PAD) among individuals with type 2 diabetes (T2D).
Research Design And Methods: We included 14,543 individuals with T2D from the UK Biobank. We defined a weighted healthy lifestyle score using nonsmoking, regular physical activity, high-quality diet, moderate alcohol consumption, optimal waist-to-hip ratio, and adequate sleep duration, and categorized into unfavorable, intermediate, and favorable lifestyles.
Article Synopsis
- The study examined the relationship between omega-3 PUFAs and stroke risk across 29 global cohorts, focusing on total, ischemic, and hemorrhagic strokes.
- Results showed that higher levels of eicosapentaenoic acid reduced the incidence of total and ischemic strokes by 17% and 18%, respectively, while docosahexaenoic acid also lowered these risks by 12% and 14%.
- The findings indicate that although higher omega-3 PUFA levels are linked to reduced total and ischemic stroke risks, there is no effect on hemorrhagic strokes.
Background: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.
Methods: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed.
Article Synopsis
- A systematic review was conducted to analyze the global transmission rates of asymptomatic SARS-CoV-2 infections, following PRISMA guidelines and utilizing data from four major databases until January 2021.
- Out of 4923 records, 15 studies involving 3917 close contacts of asymptomatic cases were included, revealing a pooled transmission rate of 1.79% for asymptomatic individuals, which is significantly lower than rates for presymptomatic (5.02%) and symptomatic infections (5.27%).
- The study found that transmission rates were higher in household settings (4.22%) compared to non-household settings (1.03%), and asymptomatic transmission rates were lower in China (1.82%) than in other
Article Synopsis
- The study examines the relationship between HIV status and health outcomes in heart failure (HF) patients, aiming to clarify whether HIV impacts readmissions and mortality in these individuals.
- Analysis included 7 cohort studies with over 58,000 HF patients, revealing that those with HIV faced a 20% higher risk of all-cause deaths and significantly increased rates of HF-related and overall readmissions.
- This research underscores the need for better management strategies for heart failure patients who are also living with HIV, given the independent risks associated with the virus.
Background: The presence of atrial fibrillation (AF) is associated with an over 2-fold increased risk of stroke, heart failure, and cardiovascular mortality. Long chain n-6 PUFAs have been suggested to have a variety of beneficial biologic effects that may reduce AF development; however, prior studies evaluating this relationship are limited.
Objectives: We prospectively evaluated the association between circulating levels of linoleic acid (LA) and arachidonic acid (AA) with incident AF.
Background: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial.
Objectives: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF.
Methods: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes.
Article Synopsis
- - The study focused on understanding genetic factors related to headaches in individuals of East Asian ancestry, specifically Han Chinese, using a large sample size of 108,855 participants, which included 12,026 headache cases from the Taiwan Biobank.
- - Significant genetic variants were identified linked to headache phenotypes: one on Chromosome 17 for broadly defined headaches (rs8072917) and another on Chromosome 8 for severe headaches (rs13272202), highlighting their potential roles in headache biology.
- - The research findings suggest that the identified genetic variants could also have implications for related health issues, and the study's methodology could be applied to diverse populations globally, paving the way for new genetic tests and drug development. *
Background: Evidence regarding dietary phytoestrogens in relation to mortality remains limited.
Objectives: The objective of the study is to examine the associations of intake of isoflavones, lignans, and coumarins with total and cause-specific mortality in US males and females.
Methods: We followed 75,981 females in the Nurses' Health Study (1984-2018) and 44,001 males in the Health Professionals Follow-up Study (1986-2018), who were free of cardiovascular disease (CVD), diabetes, or cancer at baseline.