Publications by authors named "Frank Moehrlen"
Article Synopsis
- Research shows that the production of reactive oxygen species (ROS) in mitochondria is a key factor in aging, using the organism Caenorhabditis elegans as a model.
- A newly identified mechanism involves the modification of mitochondrial proteins by methylglyoxal (MG), a byproduct of glycolysis, which increases with age when the enzyme glyoxalase-1, responsible for detoxifying MG, becomes less active.
- Enhancing the activity of glyoxalase-1 can reduce these harmful modifications and lower ROS production, leading to an extended lifespan in C. elegans, while reducing its activity has the opposite effect.
