Publications by authors named "Frank Marchlinski"
Article Synopsis
- Premature ventricular contractions (PVCs) are common in individuals with left ventricular (LV) systolic dysfunction, yet their prevalence in the general population is not well understood.
- A multicenter study evaluated the prevalence of frequent (PVCs >5%) and high burden (PVCs >10%) PVCs among patients monitored with ambulatory Holter monitors, analyzing demographics and left ventricle ejection fraction (LVEF).
- Results showed that PVCs >5% and >10% were present in 4% and 5% of participants, respectively, with higher prevalence in older males, while females had a lower occurrence of PVCs despite similar rates when LVEF <50%.
Article Synopsis
- The study focuses on the use of Left Ventricular Assist Devices (LVAD) in advanced heart failure patients, particularly those with a history of ventricular tachyarrhythmia (VTA), and aims to improve outcomes through a new intra-operative ablation protocol.
- Researchers designed a randomized clinical trial involving 100 LVAD candidates, comparing those receiving intra-operative VTA ablation against those receiving standard medical management.
- The trial will track various outcomes for an average of 18 months post-surgery, assessing VTA recurrence, adverse events, right heart function, healthcare utilization, and quality of life.
Aims: Heart failure patients with mid-range ejection fraction (HFmrEF) have overlapping clinical features, compared with patients with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). We aim to perform a meta-analysis of studies reporting long-term outcomes in HFmrEF compared with HFrEF and HFpEF.
Methods And Results: Data from 18 eligible large-scale studies including 126 239 patients were pooled.
Background: The right and left pulmonary artery branches (RPA, LPA) overlie inaccessible left atrial (LA) epicardium, containing the Bachmann bundle (BB), that participate in arrhythmia pathogenesis and offer an opportunity for natural surface epicardial mapping (NSEM).
Objective: We sought to assess the feasibility of NSEM of BB and LA roof arrhythmias.
Methods: Electrogram recording, pacing, and ablation was performed in 2 swine.
Context: Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF.
Objective: To determine the efficacy of catheter ablation compared with antiarrhythmic drug therapy (ADT) in treating symptomatic paroxysmal AF.