The effects of seasonal weather on the genotoxicity, cytokinetic properties, cytotoxicity and organochemical content of extracts of airborne particulates in Mexico City.

Extracted organic material (EOM) from PM10 airborne particles collected during three distinct seasons in Mexico City was assayed for genotoxicity, cytokinetic effects and cytotoxicity. Using sister chromatid exchange (SCE) for genotoxicity, replication index (RI) and mitotic index (MI) for cytokinetics, and microscopic evaluation (cell death) for cytotoxicity on human lymphocytes exposed to increasing concentrations of EOM, this study showed that the extent of genotoxic, cytokinetic, and cytotoxic change caused by pollutants depended at least in part on the seasonal weather. Bioactivated extracts of samplings in April (warm and dry), August (warm and rainy) and November (cool and dry) produced the highest rate of genotoxicity (SCE) in November and the lowest rate in April.