Two patients with fluoropyrimidine overdose successfully managed without uridine triacetate.

Introduction: In this case report we describe two patients with 5-fluorouracil (5-FU) overdose due to an unintentional increased infusion rate in which treatment with uridine triacetate was considered. Where previous case reports focus on the use of uridine triacetate in case of toxicity, this case report shows why it should be considered to abstain from the use of uridine triacetate.

Case Reports: The first patient is a 71-year-old woman who received 1200 mg/m 5-FU in 2 h instead of 23 h.