Publications by authors named "Frank J Walch"
Background: Pharmacological prophylaxis for venous thromboembolism (VTE) in the neurosurgical population is still a matter of debate, as the risk-to-benefit ratio is not well defined.
Objective: To further evaluate the risk-to-benefit ratio of VTE prophylaxis (VTEP) for all neurosurgical procedures.
Methods: A prospective evaluation was performed after the initiation of a VTEP protocol for 11 436 patients undergoing neurosurgical procedures over 24 mo.
Article Synopsis
- The study investigates the role of macrophage phenotypes in the formation of cerebral aneurysms and how these change over time, focusing on M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages.
- Using a mouse model, researchers assessed the effects of neutrophil blockade on macrophage contributions to aneurysms, finding a significant increase in the M1/M2 ratio as aneurysms developed.
- The findings suggest that inflammation driven by CXCL1 and neutrophils influences macrophage polarization, promoting a pro-inflammatory environment that could contribute to aneurysm progression.