Synopsis of recent research by authors named "Frank J Lowery"
- Frank J Lowery's recent research focuses on the mechanisms of immune evasion in breast cancer brain metastases, specifically how astrocytes can induce cyclin-dependent kinase 5 (Cdk5) overexpression that suppresses major histocompatibility complex (MHC-I) expression, contributing to metastatic outgrowth.
- His work in adoptive cell therapy highlights the potential of personalized neoantigen-reactive T cell receptors (TCRs) in treating metastatic colorectal cancer and the effective isolation and expansion of tumor-infiltrating lymphocytes (TILs) through targeted neoantigen stimulation.
- Lowery's studies also emphasize the identification and characterization of neoantigen-specific TCRs from various tumor types, revealing new insights into T cell reactivity and function, which may enhance the efficacy of cancer immunotherapies.