Publications by authors named "Frank Hoelscher"
Article Synopsis
- The study focuses on complex Mycobacterium tuberculosis Lineage 3 (L3) strains, which are prevalent in regions with high tuberculosis rates, analyzing 2682 strains from 38 countries.
- Researchers used advanced techniques like MIRU-VNTR genotyping and whole-genome sequencing to explore the genetic diversity and population structure of L3 strains across five continents.
- Findings indicate that L3 strains originated in Southern Asia and later spread to North-East and East Africa, offering insights that could aid in the development of new treatments and vaccines for tuberculosis.
Article Synopsis
- Generalist and specialist species have different ecological niche widths, and this study focuses on Mycobacterium tuberculosis lineage 4, a major cause of human tuberculosis.
- The analysis reveals a mix of globally distributed and geographically restricted sublineages, indicating that some are generalists while others are specialists.
- Most T cell epitopes are conserved across sublineages, but generalists show more variability; the research also suggests that the common generalist sublineage likely originated in Europe.
