The effect of pregabalin and s-ketamine in total knee arthroplasty patients: A randomized trial.

Background And Aims: Pain reduction is important for rehabilitation after total knee arthroplasty. Intra- and peri-articular infiltration with local anesthetics may be an alternative to commonly used locoregional techniques. Adding pregabalin orally and s-ketamine intravenously may further reduce postoperative pain.