A case of bupropion-induced stuttering.

Objective: Stuttering is a frequent side effect of many psychotropic drugs, particularly antidepressants.

Method: This is a case report of a woman presenting with stuttering after starting bupropion treatment for her depression.

Results: The patient's stuttering resolved after discontinuing the bupropion.

Regulation of long-term plasticity induction by the channel and C-terminal domains of GluN2 subunits.

Conventional long-term potentiation (LTP) and long-term depression (LTD) are induced by different patterns of synaptic stimulation, but both forms of synaptic modification require calcium influx through NMDA receptors (NMDARs). A prevailing model (the "calcium hypothesis") suggests that high postsynaptic calcium elevation results in LTP, whereas moderate elevations give rise to LTD. Recently, additional evidence has come to suggest that differential activation of NMDAR subunits also factors in determining which type of plasticity is induced.