Should TSPYL1 mutation screening be included in routine diagnostics of male idiopathic infertility?

Objective: To investigate a putative role of TSPYL1 in male idiopathic infertility.

Design: Clinical article.

Setting: University hospital.

Characterization of a human TSPY promoter.

Human TSPY is a candidate oncogene and is supposed to function as a proliferation factor during spermatogenesis. It is the only mammalian protein-coding gene known to be organized as a tandem repeat gene family. It is expressed at highest level in spermatogonia and to a lower amount in primary spermatocytes.