Prediction of clinical response to drugs in ovarian cancer using the chemotherapy resistance test (CTR-test).

Background: In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and the corresponding clinical response of individual patients were correlated retrospectively. Results were compared to previous recorded correlations.

Methods: The CTR-Test was performed on tumor samples from 52 ovarian cancer patients for specific chemotherapeutic drugs.

New system to predict chemotherapeutic efficacy of drug combinations in fresh tumor samples.

Background: To find the best individual chemotherapy for cancer patients, the efficacy of different chemotherapeutic drugs can be predicted by pretesting tumor samples via the chemotherapy-resistance (CTR)-Test. Although drug combinations are widely used among cancer therapy, so far only single drugs are tested by this and other tests. However, several first line chemotherapies are combining two or more chemotherapeutics, leading to the necessity of drug combination testing methods.

Rapid in vitro chemosensitivity analysis of human colon tumor cell lines.

In oncology, diagnostic assays have the potential to individualize treatment. Due to a large number of chemotherapeutic agents available, a chemosensitivity assay would be of great value for patients receiving chemotherapy. However, no broadly accepted test exists to date.