Publications by authors named "Frank Bunk"
Analysis of chromosomal aberrations and γH2A.X foci to identify radiation-sensitive ataxia-telangiectasia patients.
Mutat Res Genet Toxicol Environ Mutagen
March 2021
Article Synopsis
- - Ataxia-telangiectasia (AT) is a rare genetic disorder caused by a mutation in the ATM gene, leading to issues like chromosomal instability, cancer risk, and heightened sensitivity to radiation.
- - The study examined DNA damage and repair in lymphocytes from 8 AT patients and 10 healthy individuals after radiation exposure, finding varied responses among patients regarding γH2A.X foci and DNA repair capacity.
- - Results indicated that while γH2A.X foci may not reliably indicate radiation sensitivity due to individual mutation differences, complex chromosomal aberrations and dicentric chromosomes could serve as effective biomarkers for assessing radiation sensitivity in AT patients.