The nature and consequences of a nuclear war: lessons for prevention from Ukraine 2022.

This article attempts to put the Ukrainian conflict in the wider context of nuclear weapons possession and potential use, to point out how its conduct should affect public perception of such use, and the urgency for effective nuclear arms control measures including a determined resolve to implement the United Nations' 2017 Treaty on the Prevention of Nuclear Weapons.

Nuclear war and public health: preparedness, protection and the case for prevention.

Background: According to the Stockholm International Peace Research Institute, the year 2018 saw a continuing 'drift into global instability' in which 'both the USA and Russia are on a path of strategic nuclear (weapons) renewal' with 3750 nuclear bombs globally deployed 'ready to fire'. Treaties are being abrogated with increasingly aggressive language exchanged, and discredited tactics such as 'limited use' revived. These developments risk an amplifying cascade of nuclear weapon fire, whether started by intent, miscalculation or unintentionally.

Ionising radiation and childhood leukaemia revisited.

Increased incidences of childhood acute leukaemia were noted among survivors of the atomic bombings of Hiroshima and Nagasaki. In Western societies, Childhood Acute Lymphoblastic Leukaemia has a distinct epidemiology peaking at 3 years old. Exposure to ionising radiation is an established hazard but it is difficult to gauge the precise risk of less than 100 mSv.

Can the health of a nation be correlated to its state of internal peace?

The Institute for Economics and Peace has ranked 162 territories within the United Nations according to how they score on a scale of 1.0 (most peaceful) to 5.0 (least peaceful) in a 'Global Peace Index' (GPI).

Dangers associated with civil nuclear power programmes: weaponization and nuclear waste.

The number of nuclear power plants in the world rose exponentially to 420 by 1990 and peaked at 438 in 2002; but by 2014, as closed plants were not replaced, there were just 388. In spite of using more renewable energy, the world still relies on fossil fuels, but some countries plan to develop new nuclear programmes. Spent nuclear fuel, one of the most dangerous and toxic materials known, can be reprocessed into fresh fuel or into weapons-grade materials, and generates large amounts of highly active waste.

Blood transfusion and the World Wars.

This article summarizes the remarkable development in the science and practice of blood transfusion during the 20 years either side of 1900, progressing through the challenges of surgical vascular access, the propensity of shed blood to clot and the more mysterious apparently arbitrary acute reactions (later revealed as due to blood group incompatibility), to describe in more detail, the developments at the Western Front, then giving a précis of the advances in the interwar years through to the mid-twentieth-century 'blood-banking'.

External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflection.

Jean-Pierre Allain and colleagues argue that, while unintended, the foreign aid provided for blood transfusion services in sub-Saharan Africa has resulted in serious negative outcomes, which requires reflection and rethinking.

Thomas Addis, MD (1881-1949): Scottish-American clinical laboratory researcher, social activist and pioneer of renal medicine.

Addis was born and educated in Edinburgh, from the University of which he graduated MB in 1905, and MD in 1908, in which year he also gained membership of Edinburgh's Royal College of Physicians. After researching disordered haemostasis associated with various clinical conditions, he spent over a year in Germany: in Berlin with Dr. E.

Which bio-weapons might be used by terrorists against the United Kingdom?

The properties of potential biological weapon agents for bioterrorism include a consistent effect at low dosage and short incubation period in a population of low immunity, being difficult to treat, able to be produced in bulk, stable in storage and readily disseminated. Possible agents include smallpox, haemorrhagic fever viruses, anthrax, tularaemia and plague. The example of Severe Acute Respiratory Syndrome (SARS) demonstrates the possible consequences of an act of bioterrorism, but also the necessary global response.

Genotype at the secretor blood group locus is a determinant of plasma von Willebrand factor level.

Previous reports on the effect of Secretor and Lewis blood groups on plasma factor VIII-von Willebrand factor (FVIII-VWF) levels have produced conflicting findings. To determine whether either or both loci can influence plasma FVIII-VWF complex levels, we studied the relationship between Secretor and Lewis genotypes, determined definitively using polymerase chain reaction-restriction fragment length polymorphism analysis, and plasma FVIII coagulant activity (FVIII:C) and VWF antigen (VWF:Ag) levels in 136 healthy volunteers. Overall, significantly higher VWF:Ag levels were found in those individuals homozygous for the Se allele (genotype SeSe) than in those heterozygous for the Se allele (P < 0.

Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels.

To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the ABH antigenic determinants carried on N-linked glycans of vWF, we studied 158 group A and group O healthy volunteers. vWF antigen (vWF:Ag) and factor VIII antigen (FVIII:Ag) levels were highest in A(1)A(1) individuals and higher in A(1)O(1) than in A(2)O(1) or O(1)O(1) individuals. Plasma A transferase activity and the amount of A antigen expressed per unit vWF (AvWF) were significantly higher in A(1)A(1) than in A(1)O(1) individuals and higher in A(1)O(1) than in A(2)O(1) individuals.