Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice.

Background: TLR ligands can promote Th1-biased immune responses, mimicking potent stimuli of viruses and bacteria.

Aim: To investigate the adjuvant properties of dual TLR2/7 ligands compared to those of the mixture of both single ligands.

Methods: Dual TLR2/7 ligands: CL401, CL413, and CL531, including CL264 (TLR7-ligand) and PamCysK (TLR2-ligand), were used.