Publications by authors named "Frank Biggemann"
Gender differences in renal tubular taurocholate transport.
Naunyn Schmiedebergs Arch Pharmacol
June 2005
Article Synopsis
- Bile acids are mostly reabsorbed in the kidneys and not excreted in urine, primarily through a sodium-dependent transporter called ASBT in proximal tubular cells.
- Male and female rats show significant differences in the accumulation and clearance of taurocholate, with males exhibiting higher uptake and clearance rates.
- Estrogen appears to inhibit taurocholate transport in male rats, while testosterone treatment does not significantly affect female rats, suggesting that sex hormones play a role in how kidneys handle bile acids.