Publications by authors named "Francoise Meisch"

Article Synopsis
  • - Recent genomic advances have shed light on how replication origins in multicellular organisms are activated, but many mechanisms remain not fully understood.
  • - Studies in yeast have led to the development of convincing models for how these origins are selected, highlighting both a general mechanism and a surprising variety of strategies.
  • - The role of chromatin structure in forming pre-replication complexes is crucial for origin activation, and caution is needed when applying yeast findings to more intricate vertebrate systems.
View Article and Find Full Text PDF
Article Synopsis
  • Researchers mapped replication origins in 1% of the human genome in HeLa cells, discovering 283 origins—ten times more than previously found.* -
  • The study found that these origins are clustered in GC-rich areas and usually overlap with transcriptional regulatory elements, linking them to gene regulation.* -
  • Interestingly, half of the identified replication sites lack open chromatin configurations, indicating a complex relationship between replication initiation and gene regulation.*
View Article and Find Full Text PDF