Publications by authors named "Francoise Meisch"
Brief Funct Genomics
January 2011
Article Synopsis
- - Recent genomic advances have shed light on how replication origins in multicellular organisms are activated, but many mechanisms remain not fully understood.
- - Studies in yeast have led to the development of convincing models for how these origins are selected, highlighting both a general mechanism and a surprising variety of strategies.
- - The role of chromatin structure in forming pre-replication complexes is crucial for origin activation, and caution is needed when applying yeast findings to more intricate vertebrate systems.
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Proc Natl Acad Sci U S A
October 2008
Article Synopsis
- Researchers mapped replication origins in 1% of the human genome in HeLa cells, discovering 283 origins—ten times more than previously found.*
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- The study found that these origins are clustered in GC-rich areas and usually overlap with transcriptional regulatory elements, linking them to gene regulation.*
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- Interestingly, half of the identified replication sites lack open chromatin configurations, indicating a complex relationship between replication initiation and gene regulation.*
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