Efficacy of topical versus intravenous tranexamic acid in spinal deformity.

Purpose: To compare topical tranexamic acid versus intravenous tranexamic acid in reducing intra- and postoperative blood loss and transfusion rate in deformity patients.

Materials And Method: We performed a retrospective cohort study with posterior fusion deformity patients, between 2009 and 2016. Patients were categorized in 4 groups: "No TXA" (n = 35) if the wound was packed with saline soaked sponges, "IV TXA" (n = 37) the patient received 20 mg/kg bolus at the beginning of the surgery followed by continuous infusion of 1 mg/kg/hr until closure, "Topical TXA" (n = 23) the wound was packed with sponges soaked in 6 g of TXA diluted in a 3 L saline solution, or "Combined TXA" (n = 86) the patient received both IV and topical TXA.