Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89.

Purpose: To improve outcome for children with nonmetastatic rhabdomyosarcoma and to reduce systematic use of local therapy.

Patients And Methods: Five hundred three previously untreated patients aged from birth to 18 years, recruited between 1989 and 1995, were allocated to one of six treatment schedules by site and stage.

Results: Five-year overall survival (OS) and event-free survival (EFS) were 71% and 57%, respectively.