Publications by authors named "Francoise Dartiguelongue"
Article Synopsis
- Drug development requires a thorough examination of pharmacokinetics, which includes understanding how a drug is absorbed, distributed, metabolized, and excreted.
- MALDI mass spectrometry imaging (MSI) is a method used to study the distribution of drugs and their metabolites without the need for radiolabeling, but it often faces sensitivity issues.
- A novel approach called on-tissue chemical derivatization (OTCD) was used to enhance the sensitivity of MALDI-MSI for acetaminophen, allowing researchers to accurately study its distribution in tissues at high spatial resolution.
