CCAAT/enhancer-binding protein-homologous protein expression and transcriptional activity are regulated by 3',5'-cyclic adenosine monophosphate in thyroid cells.

The cAMP pathway activates p38-MAPKs in the FRTL-5 rat thyroid cell line, contributing to the increased expression of the Na+/I- symporter (NIS) mRNA. This study investigates the cAMP-dependent expression and transcriptional activity of the p38-MAPK substrate CCAAT/enhancer-binding protein-homologous protein (CHOP). CHOP is expressed in the rat thyroid gland and in confluent PCCL3 and FRTL-5 cells.

Thyroid hormone regulates the expression of NeuroD/BHF1 during the development of rat cerebellum.

During the postnatal development of the rat cerebellum, there is an extensive proliferation of granular neurones in the external layer, followed by their migration and differentiation in the internal layer. These processes are impaired by neonatal hypothyroidism and can be restored by thyroid hormone therapy. They are also abolished in transgenic mice in which the neuroD gene is not expressed.