Publications by authors named "Francoise Bronsard"
Article Synopsis
- The study investigates bioavailable testosterone (BT) levels in men to diagnose hypogonadism, comparing measured (aBT) and calculated (cBT) testosterone values and highlighting the impact of different association constants.* -
- In a sample of 503 healthy men aged 20-74, it was observed that testosterone levels generally decrease with age while sex hormone-binding globulin (SHBG) levels increase, affecting BT calculations.* -
- The findings indicate that the lower normal serum aBT concentration is between 2.30 and 2.72 nmol/L, while calculated levels can vary significantly depending on the association constants used, suggesting the need for optimized parameters for more accurate measurement.*
Background: Bioavailable testosterone (BT), circulating testosterone not bound to sex hormone-binding globulin (SHBG), is thought to easily penetrate cells. We compared BT measurements obtained by assays with those obtained by calculation with different testosterone association constants.
Methods: We obtained sera from 2 groups of hypogonadal men [group 1 (G1), 1421 samples; group 2 (G2), 170 samples] and a group of healthy men [group 3 (G3), 109 samples].