Publications by authors named "Francois-Daniel Ardellier"
A novel methylation class, "neuroepithelial tumor, with PLAGL1 fusion" (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor with recurrent histopathological features suggesting an ependymal differentiation. Because of the recent identification of this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present a detailed series of nine cases of PLAGL1-fused supratentorial tumors, reclassified from a series of supratentorial ependymomas, non-ZFTA/non-YAP1 fusion-positive and subependymomas of the young.
View Article and Find Full Text PDFArticle Synopsis
- Visual dysfunction is common in patients with non-functioning pituitary macroadenoma, yet the effectiveness of Optical Coherence Tomography (OCT) in assessing this issue remains unclear.
- A 6-year study involving 20 patients aimed to evaluate the impact of NFPM on neuro-axonal loss by measuring retinal nerve fiber layer (RNFL) thickness over time and analyzing the relationship between OCT changes and optic chiasm compression.
- Findings showed that 40% of patients had RNFL alterations at diagnosis, and 20% experienced thickness reduction during follow-up, but overall visual acuity and field remained stable, indicating OCT may not reliably predict visual dysfunction in these cases.
Article Synopsis
- * The majority of the patients had severe COVID-19, with 90% showing abnormal ASL perfusion, particularly hypoperfusion in the temporal poles and frontal lobes, even if traditional MRI scans appeared normal.
- * The findings highlight that over 80% of these patients exhibited significant brain perfusion deficits, suggesting that neurological complications in COVID-19 can occur independently of visible lesions on standard MRI scans.
Article Synopsis
- This study aimed to analyze the brain MRI and FDG-PET/CT findings in 112 COVID-19 patients with neurological issues during recovery, focusing on changes over time and cognitive outcomes.
- Initial MRIs revealed various complications, including brain swelling and strokes, while some conditions showed stabilization or improvement during follow-up; however, 13% developed new issues post-recovery.
- Overall, although most patients improved, a small percentage faced new complications, and there was an observed 3.2% loss in grey matter volume during an average follow-up of five months.
Evaluation of neuroradiology emergency MRI interpretations: low discrepancy rates between on-call radiology residents' preliminary interpretations and neuroradiologists' final reports.
Eur Radiol
October 2022
Article Synopsis
- The study assessed the accuracy of on-call radiology residents when interpreting brain and spine MRI exams, finding that overall discrepancies were low but some serious mistakes occurred, particularly among second-year residents.
- During the analysis of 328 MRI scans over 13 months, level 2 and level 3 errors (important and major corrections) were noted, with a 16% overall discrepancy rate and a 5.5% rate for major errors.
- Most significant errors related to cerebrovascular issues, and while senior residents performed better than second-year residents, the overall high accuracy suggests that many exams were interpreted correctly without major clinical consequences.
Clinical Efficacy of Reduced-Dose Gadobutrol Versus Standard-Dose Gadoterate for Contrast-Enhanced MRI of the CNS: An International Multicenter Prospective Crossover Trial (LEADER-75).
AJR Am J Roentgenol
November 2021
Gadobutrol and gadoterate are widely used macrocyclic gadolinium-based contrast agents. Given gadobutrol's higher T1 relaxivity, a reduced gadobutrol dose should achieve essentially equivalent diagnostic efficacy as a standard dose of gadoterate. The purpose of our study was to show efficacy of a 25% reduced dose of gadobutrol is noninferior to 100% standard dose of gadoterate for contrast-enhanced MRI of the CNS.
View Article and Find Full Text PDFBackground: Infectious and tropical diseases (ID) physicians are needed now more than ever to tackle existing and emerging global threats. However, in many countries, ID is not recognized as a qualifying specialty. The creation of ID residency in 2017 in France offers the opportunity to know how and why the specialty is chosen by medical students.
View Article and Find Full Text PDFObjective: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations.
Methods: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI.
Results: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years.
Article Synopsis
- Background: The study examines brain MRI abnormalities in patients with severe COVID-19 (SARS-CoV-2) and identifies potential neurological issues related to the virus.
- Methods: Researchers analyzed data from 37 hospitalized patients who had neurological symptoms and abnormal brain MRIs between March and April 2020, excluding cases with ischemic strokes or unrelated chronic lesions.
- Results: The patient cohort, primarily older men, exhibited various neurological symptoms, with MRI findings showing significant abnormalities in brain regions including the medial temporal lobe and evidence of microhemorrhages, suggesting COVID-19's impact on brain structure.
Objectives: This study analysed CT patterns of the acute dissected aortic arch using original biometric features along with comparison with normal aortas.
Methods: The diagnostic CT scans of 57 patients (42 males, age (mean ± SD: 64.5 ± 13.