Publications by authors named "Francois le Pelletier"
Article Synopsis
- Indeterminate dendritic cell histiocytosis (IDCH) is a rare condition marked by a buildup of specific histiocytes, with particular immunophenotypic features and clinical presentations, mostly in older adults.
- The study analyzed 43 cases, showing that many patients had skin or lymph node involvement, and a significant number had related blood cancers or other histiocytic diseases.
- Genetic analyses identified common mutations (like KRAS and BRAF) and unique gene fusions, helping to clarify IDCH's molecular profile and its potential impact on diagnosis and treatment strategies.
Proliferative verrucous leukoplakia (PVL) is an oral mucosa lesion with a high rate of malignant transformation. The diagnosis is often difficult, especially when the initial lesion is a simple homogeneous white leukoplakia, and when located only on the gingiva or palate. Moreover, the anatomopathological analysis is non-specific in the initial stages.
View Article and Find Full Text PDFBackground: Deep cutaneous fungal infections (DCFIs) are varied in immunosuppressed patients, with few data for such infections in solid-organ transplant recipients (s-OTRs).
Objective: To determine DCFI diagnostic characteristics and outcome with treatments in s-OTRs.
Methods: A 20-year retrospective observational study in France was conducted in 8 primary dermatology-dedicated centers for s-OTRs diagnosed with DCFIs.
Glomeruloid haemangioma (GH) is considered a specific marker of POEMS syndrome, despite some published GH cases unrelated to POEMS syndrome. To present two cases with GH and atypical presentations of Erdheim-Chester disease (ECD) or POEMS syndrome, as well as a retrospective monocentric study of histologically-confirmed GH. Clinical, biological and histological data of the patients is presented.
View Article and Find Full Text PDFLivedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid vasculopathy and the efficacy of treatments. Patients enrolled had typical livedoid vasculopathy both clinically and histologically.
View Article and Find Full Text PDFBackground: Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis with possible cutaneous-specific involvement.
Objectives: We sought to describe the clinical, pathological, and molecular features of the cutaneous manifestations of 40 patients with ECD identified from a cohort of 123 patients.
Methods: Confirmed cases of patients with ECD were included in a single-center retrospective observational study.
Article Synopsis
- A study analyzed 119 granular cell tumors in skin from 114 patients over ten years to evaluate histopathological features, specifically looking for vascular invasion.
- The majority of tumors were classified as benign, with vascular invasion found in 23% of cases, but no malignant tumors were detected.
- Findings suggest that while local invasive features are common in these tumors, vascular invasion may not indicate a worse clinical outcome.
Skin biopsies were performed in a patient with livedoid and necrotic lesions of the forearm. Periodic acid-Schiff-stained and birefringent Maltese cross-patterned foreign bodies were observed in capillary vessels. It was consistent with the diagnosis of intra-arterial injections of a substance containing corn starch.
View Article and Find Full Text PDFObjective: To describe dermatologic manifestations of the antiphospholipid syndrome (APS) and to investigate possible correlations between livedo reticularis and other APS manifestations.
Methods: We conducted a single-center study of 200 consecutive patients with primary or systemic lupus erythematosus-related APS. To qualify for the study, patients had to fulfill clinical and laboratory criteria from the most recent international consensus statement on classification of definite APS.
Background: Laugier-Hunziker syndrome is a rare acquired hyperpigmentation of the oral mucosa and lips which is often associated with longitudinal melanonychia. We report two patients exhibiting the classical features of Laugier-Hunziker syndrome with additional and previously unreported conjunctival and penile pigmentation.
Patients And Methods: Two patients presented with a history of progressive acquired macular pigmentation of the oral mucosa, the lips, the ocular conjunctiva and the penis.