Publications by authors named "Francois de Kermenguy"
. Severe radiation-induced lymphopenia occurs in 40% of patients treated for primary brain tumors and is an independent risk factor of poor survival outcomes. We developed anframework that estimates the radiation doses received by lymphocytes during volumetric modulated arc therapy brain irradiation.
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- The study investigates the out-of-field dose delivered during external photon beam radiation therapy, as it may lead to a higher risk of second cancers and affect immune system efficiency in radio-immunotherapy treatments.
- Traditional methods for estimating out-of-field doses are complex and not suitable for clinical use, prompting the exploration of deep learning techniques for more effective dose map prediction.
- A 3D U-Net model, trained on data from 3,151 pediatric patients, demonstrated promising results in estimating out-of-field doses, achieving low error rates in both training and validation, indicating potential for clinical application.
Article Synopsis
- Radiation-induced lymphopenia (RIL) means that there are fewer lymphocytes, a type of white blood cell, in the blood after someone undergoes radiotherapy for cancer.
- Combining radiotherapy with immunotherapy could help reduce RIL and make treatments work better together, but we don’t fully understand why RIL happens yet.
- This review aims to explain RIL in detail, look at new research about it, and think about new ways to treat patients who are getting both radiotherapy and immunotherapy.
A growing body of scientific evidence indicates that exposure to low dose ionizing radiation (< 2 Gy) is associated with a higher risk of developing radio-induced cancer. Additionally, it has been shown to have significant impacts on both innate and adaptive immune responses. As a result, the evaluation of the low doses inevitably delivered outside the treatment fields (out-of-field dose) in photon radiotherapy is a topic that is regaining interest at a pivotal moment in radiotherapy.
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