Publications by authors named "Francois Xavier Leandri"

Article Synopsis
  • Cervical cancer (CC) is a leading cause of death that predominantly arises from HPV infections, and underserved women face higher risks due to lower screening rates.
  • A cluster randomized trial will assess the impact of financial incentives and different self-sampling return methods on increasing HPV screening rates among 10,000 women aged 30-65 in deprived areas of France.
  • The study has received ethical approval, requires no formal consent, and will collect follow-up data through the National Health Insurance to evaluate if incentives can raise HPV self-sampling return rates by at least 10%.
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Background: HPV vaginal self-sampling can be an alternative for women refusing cytological screening.

Objectives: To describe HR-HPV types in 35-69 years old women from low socioeconomic groups not attending regular cytological screening in Marseille, France.

Study Design: A cervical screening campaign using HR-HPV self-sampling including 22,702 women aged 35-69 years living in low socioeconomic districts of Marseille was organized.

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The non-participation to cervical screening is the major determinant in the risk of mortality due to cervical cancer. In France, around 40% of women do not participate to regular screening. The cultural or economic barriers for performing screening by Pap test are numerous; one of the most frequent is the refusal of gynaecological examination.

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Self-sampling using vaginal swabs could be a valuable alternative to screen for cervical cancer for women who do not attend regular cytological screening. The aim of this study was to determine the prevalence of high and low-risk HPV types and of HPV type 16 and 18 DNA load in self-collected vaginal swabs from 35- to 69-year-old Southern French women of low socioeconomic level or migrant populations who do not attend regular cervical screening. A good concordance (93.

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Individual cervical screening with pap-smears is the major cause of the decrease in incidence and mortality of cervical cancer in France since more than 30 years. But, for the last ten years, the decrease in mortality is limited due to the persistence of poor prognostic cases and the insufficiency of treatment efficacy in such patients. These cases are mostly observed in women who did not participate to regular screening.

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