Publications by authors named "Francois Thouy"
Regional citrate anticoagulation use in intermittent hemodialysis is limited by the increased risk of metabolic complications due to faster solute exchanges than with continuous renal replacement therapies. Several simplifications have been proposed. The objective of this study was to validate a mathematical model of hemodialysis anticoagulated with citrate that was then used to evaluate different prescription scenarios on anticoagulant effectiveness (free calcium concentration in dialysis filter) and calcium balance.
View Article and Find Full Text PDFBackground: Inconsistent results from COVID-19 studies raise the issue of patient heterogeneity.
Objective: The objective of this study was to identify homogeneous subgroups of patients (clusters) using baseline characteristics including inflammatory biomarkers and the extent of lung parenchymal lesions on CT, and to compare their outcomes.
Design: Retrospective single-center study.
Background: The clinical significance of early-onset acute kidney injury (EO-AKI) and recovery in severe COVID-19 intensive care unit (ICU) patients is poorly documented.
Objective: The aim of the study was to assess the epidemiology and outcome of EO-AKI and recovery in ICU patients admitted for SARS-CoV-2 pneumonia.
Design: This was a retrospective single-centre study.
Objective: COVID 19 is often associated with hypercoagulability and thromboembolic (TE) events. The aim of this study was to assess the characteristics of hypercoagulability and its relationship with new-onset TE events and the composite outcome of need for intubation and/or death in intensive care unit (ICU) patients admitted for COVID.
Design: Prospective observational study.
Background & Aims: The intensity and duration of the catabolic phase in COVID-19 patients can differ between survivors and non-survivors. The purpose of the study was to assess the determinants of, and association between, nitrogen balance trajectories and outcome in critically ill COVID-19 patients.
Methods: This retrospective monocentric observational study involved patients admitted to the intensive care unit (ICU) of the University Hospital of Clermont Ferrand, France, from January 2020 to May 2021 for COVID-19 pneumonia.
Background: Stress hyperglycemia can persist during an intensive care unit (ICU) stay and result in prolonged requirement for insulin (PRI). The impact of PRI on ICU patient outcomes is not known. We evaluated the relationship between PRI and Day 90 mortality in ICU patients without previous diabetic treatments.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses a study aimed at evaluating non-invasive oxygenation treatments for ICU patients with acute respiratory failure who have do-not-intubate orders, focusing on quality of life and discomfort, not just survival.
- It outlines a multicentre observational study comparing different oxygenation strategies: high-flow nasal oxygen therapy (HFOT), NIV switching with HFOT, and NIV with standard oxygen, with a goal to include at least 330 patients.
- The study has received ethical approval, will involve informed consent from participants, and aims to publish findings in peer-reviewed journals with trial registration number NCT03673631.