Publications by authors named "Francois Rivard"
Aging is associated with impaired neovascularization in response to ischemia. MicroRNAs are small noncoding RNAs emerging as key regulators of physiological and pathological processes. Here we investigated the potential role of microRNAs in endothelial cell senescence and age-dependent impairment of neovascularization.
View Article and Find Full Text PDFBackground And Aims: MicroRNA (miR)-146 is a key regulator of inflammation, endothelial activation and atherosclerosis. This study sought to define its potential role for the modulation of ischemia-induced neovascularization in atherosclerotic conditions.
Methods: Next generation sequencing and qRT-PCR analyses were used to compare microRNA expression in the ischemic muscles of hypercholesterolemic ApoE-deficient (ApoE) mice vs.
Article Synopsis
- - High oxygen exposure in prematurely born infants can cause long-term cardiovascular issues, including problems with blood flow and blood vessel formation in adulthood.
- - Adult mice previously exposed to high oxygen levels show poor recovery from restricted blood flow due to reduced blood vessel growth and increased tissue damage.
- - The negative effects of neonatal hyperoxia involve increased oxidative stress and decreased key proteins that aid blood vessel formation, as well as fewer pro-angiogenic cells essential for healing.