Developing the Ce and La pair as companion positron emission tomography diagnostic isotopes for Ac and Th radiotherapeutics.

Developing targeted α-therapies has the potential to transform how diseases are treated. In these interventions, targeting vectors are labelled with α-emitting radioisotopes that deliver destructive radiation discretely to diseased cells while simultaneously sparing the surrounding healthy tissue. Widespread implementation requires advances in non-invasive imaging technologies that rapidly assay therapeutics.

A reverse U/Th radionuclide generator for targeted alpha therapy applications.

Purpose: Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Due to its short half-life, Th must be provided through a radionuclide generator system from its parent U (20.

Large-Scale Production of Te and Sb for Radiopharmaceutical Applications.

Radionuclides find widespread use in medical technologies for treating and diagnosing disease. Among successful and emerging radiotherapeutics, Sb has unique potential in targeted therapeutic applications for low-energy electron-emitting isotopes. Unfortunately, developing Sb-based drugs has been slow in comparison to other radionuclides, primarily due to limited accessibility.

Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix.

A new method has been developed for the isolation of Ra, in high yield and purity, from a proton irradiated Th matrix. Herein we report an all-aqueous process using multiple solid-supported adsorption steps including a citrate chelation method developed to remove >99.9% of the barium contaminants by activity from the final radium product.

Nuclear excitation functions of proton-induced reactions (E = 35 - 90 MeV) from Fe, Cu, and Al.

Fe, Cu, and Al stacked foils were irradiated by 90 MeV protons at the Los Alamos Neutron Science Center's Isotope Production Facility to measure nuclear cross sections for the production of medically relevant isotopes, such as Mn, Mn, Cr, Co, Co and Ni. The decay of radioactive isotopes produced during irradiation was monitored using high-purity germanium gamma spectroscopy over the months following irradiation. Proton fluence was determined using the Al(p,x)Na, Cu(p,x)Zn Cu(p,x)Zn, and Cu(p,x)Co monitor reactions.

Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes.

Introduction: The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the development of bifunctional chelating agents that can successfully deliver these Bi radioisotopes to the tumor cells.