First validation of the G-8 geriatric screening tool in older patients with glioblastoma.

Introduction: Management of glioblastoma, with a very poor prognosis, remains a challenge in older patients because of coexisting comorbidities and the increased risk of toxic treatment effects. The use of screening tools to identify vulnerable patients is essential. This study was performed to establish whether the G8 scale can be used for screening older patients with glioblastoma.

Incidence, Clinical Presentation, and Associated Factors of Microscopic Colitis in Northern France: A Population-Based Study.

Objective: To date, there are no epidemiological data on microscopic colitis (MC) in France. The aim of this study was to determine the incidence of MC in the Somme department in Northern France, to evaluate clinical characteristics, and to search for risk factors for both collagenous colitis (CC) and lymphocytic colitis (LC).

Design: Between January 1, 2005, and December 31, 2007, four pathology units in the Somme department recorded all new cases of MC diagnosed in patients living in the area.

Dicationic lipophosphoramidates as DNA carriers.

Lipophosphoramidates with two different permanent cations as polar heads were synthesized and evaluated for their gene transfer activity. Physicochemical measurements (particle size, zeta potentials) and gel retardation assays were also performed. In vitro biological evaluation was conducted with A542 and HeLa cell lines, and cytotoxicity determined by a chemiluminescent assay.

Lipophosphoramidates as lipidic part of lipospermines for gene delivery.

The DNA compacting properties of polyamines (especially spermine) are well-known, hence the use of spermine as the cationic part in several synthetic DNA carriers. Here, we describe the synthesis of modified spermines, with a "lipophosphoramidate" as the lipidic part, and their use for efficient in vitro transfection. Physicochemical measurements (particle size, zeta potentials, pKa determination) and gel retardation assays were also performed.

Synthesis and photocytotoxic activity of new chlorin-polyamine conjugates.

This paper reports the synthesis of new chlorin-polyamine conjugates designed to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested against human chronic myelogenous leukemia cells (K562) and compared to the effects of Photofrin II and chlorin e6.

Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: potential agents for photodynamic therapy of cancers.

An efficient five-step synthesis method was developed to obtain tritolylporphyrin and protoporphyrin IX polyamine conjugates. These compounds were composed of either one polyamine unit (spermidine or spermine) covalently tethered to monocarboxyphenyl tritolylporphyrin or two molecules of polyamines borne by protoporphyrin IX. In each compound, an aliphatic spacer arm is linked to the N(4) polyamine position.

Production of soy protein concentrates using a combination of electroacidification and ultrafiltration.

Soy protein concentrates produced by combining electroacidification and dead-end ultrafiltration with a membrane of 100 kDa (pH 7 and 6) were compared with concentrates produced by ultrafiltration (pH 9) and a traditional acid precipitation procedure at pH 4.5. Mineral removal during ultrafiltration (mainly potassium, phosphorus, and calcium) was enhanced for the pH 6 electroacidified extract, compared to the extract at pH 9.

[Pilomatrix carcinoma: histologic and immunohistochemical features. Two studies].

Malignant pilomatricoma is a rare malignant hair follicle tumor, that was initially described in 1980. Histologically, it shares common features with the more frequent, which benign pilomatricoma, makes its diagnosis difficult. It is a deep dermis-hypodermis epithelial tumor, well circumscribed, with no relation with the epidermis.

Effects of type of added salt and ionic strength on physicochemical and functional properties of casein isolates produced by electroacidification.

A procedure developed for soybean protein precipitation which was based on electrodialysis was tested for the production of acid casein from reconstituted skim milk. In a previous paper, the performance of bipolar membrane electroacidification (BMEA) was evaluated under different conditions of ionic strength (micro(added) = 0, 0.25, 0.

Identification of Skim Milk Electroacidification Fouling: A Microscopic Approach.

Bipolar membrane electroacidification (BMEA) was used to produce high-purity bovine milk casein isolates. However, a deposit suggested to be a mix of calcium and magnesium salts was observed on the cation-exchange membrane (CEM) side in contact with the base. The aim of the present study was to complete the identification of the deposit formed on CMX membrane during bipolar membrane electroacidification of skim milk, and to characterize its physical structure at the interfaces of CEM.