Steroids and adrenomedullin growth patterns in human ovarian cancer cells: estrogenic-regulation assay.

Objective: Adrenomedullin is a multifunctional regulatory peptide with mitogenic and angiogenic capabilities. Objectives in this study were: (1) to describe the effects of adrenomedullin and anti-adrenomedullin antibodies on ovarian carcinoma cell proliferation, and (2) to assess the estradiol regulation of adrenomedullin metabolism.

Methods: We assessed the effects of estradiol, adrenomedullin, and anti-adrenomedullin antibodies on cell growth in three human ovarian cell lines.

Expression of adrenomedullin in human ovaries, ovarian cysts and cancers. Correlation with estrogens receptor status.

Objective: To investigate the expression of adrenomedullin (AM) in benign and malignant ovarian tissues and its correlation with estrogen receptors (ERs) mRNA status.

Study Design: Ovarian carcinoma cell lines, normal ovaries, serous cysts and cancers were analyzed using real-time polymerase chain reaction (PCR) in order to quantify adrenomedullin and ERs mRNAs expression. Some ovarian samples were submitted to laser-capture microdissection to determine the differential expression of target genes in epithelium and stroma.

Achieving symmetry in unilateral breast reconstruction: 17 years experience with 683 patients.

Breast symmetry is one of the most important parameters of patient satisfaction in breast reconstruction. We undertook this retrospective study to determine whether autologous reconstruction requires opposite-breast procedures less often to achieve symmetry than do non-autologous techniques. The records of 683 patients who underwent delayed breast reconstruction between March 1983 and March 2000 were reviewed.

[Standards, Options and Recommendations 2000: non metastatic endometrial cancer].

Context: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French Cancer Centers (FNCLCC), the 20 French Cancer Centers, and specialists from French Public Universities, General Hospitals and Private Clinics, and some specialists learned societies. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. The SORs are developed using a methodology based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery.

Pfannenstiel versus Maylard incision for cesarean delivery: A randomized controlled trial.

Objective: To compare the Pfannenstiel incision with transverse muscle-cutting Maylard incision in women who had cesarean delivery.

Methods: Patients were assigned randomly to a Pfannenstiel or Maylard incision. Postoperative treatment was similar for each group.