Publications by authors named "Francois Khazoom"
This is a comprehensive review of intraoperative, early postoperative, and late postoperative complications of Per Oral Endoscopic Myotomy with a focus on prevention, intraoperative management, and postoperative management.
View Article and Find Full Text PDFSecondary brain injury following hemorrhagic shock (HS) is a frequent complication in patients, even in the absence of direct brain trauma, leading to behavioral changes and more specifically anxiety and depression. Despite preclinical studies showing inflammation and apoptosis in the brain after HS, none have addressed the impact of circulating mediators. Our group demonstrated an increased uric acid (UA) circulation in rats following HS.
View Article and Find Full Text PDFArticle Synopsis
- Multiorgan failure can occur after traumatic hemorrhagic shock due to ischemia-reperfusion injury, with circulating uric acid (UA) playing a role in inflammation and cell death.
- A study using a mouse model showed that treating with a recombinant uricase during resuscitation significantly lowered UA levels and reduced liver damage and enteric permeability issues caused by hemorrhagic shock.
- The findings suggest that targeting UA may help minimize organ damage in trauma patients, highlighting its potential as a therapeutic strategy.
Background: Multiple organ failure can develop after hemorrhagic shock (HS). Uric acid (UA) is released from dying cells and can be proinflammatory. We hypothesized that UA could be an alternative mediator of organ apoptosis and inflammation after HS.
View Article and Find Full Text PDFObjectives: To characterize rates, reasons for, and associated predictors for emergency department (ED) visits after breast cancer (BC) surgery.
Methods: All women over 65 years undergoing curative surgery for non-metastatic incident BC (1998-2012) were identified using Quebec's universal healthcare administrative databases. Reasons for ED visits within 45days of operation were reported.
S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study.
Scand J Trauma Resusc Emerg Med
November 2017
Background: Following tissue injury after trauma, the activation of innate immune pathways results in systemic inflammation, organ failure and an increased risk of infections. The objective of this study was to characterize the kinetics of the S100A8/S100A9 complex, a new-recognized alarmin, as well as its soluble receptor sRAGE, over time after trauma as potential early biomarkers of the risk of organ damage.
Methods: We collected comprehensive data from consenting patients admitted to an ICU following severe trauma.