Efficacy of topical diclofenac diethylamine gel in osteoarthritis of the knee.

Objective: To assess the efficacy and safety of topical diclofenac diethylamine gel, 1.16%, 4 g applied qid for 3 weeks to relieve the symptoms of osteoarthritis (OA) of the knee.

Methods: Patients with OA of the knee washed out their OA medications for at least 5 drug half-lives.