Publications by authors named "Francois Come Ferre"
Background: Decellularized extracellular matrix (dECM) has been proposed as a useful source of biomimetic materials for regenerative medicine due to its biological properties that regulate cell behaviors. The present study aimed to investigate the influence of decellularized ECM derived from dental pulp stem cells (DPSCs) on gingival fibroblast (GF) cell behaviors. Cells were isolated from dental pulp and gingival tissues.
View Article and Find Full Text PDFExtracellular Matrix Derived From Dental Pulp Stem Cells Promotes Mineralization.
Front Bioeng Biotechnol
January 2022
Article Synopsis
- The extracellular matrix (ECM) is crucial for physiological functions, varying by tissue type and influencing cell behavior, particularly in dental pulp stem cells (DPSCs).
- This study focused on identifying ECM proteins from DPSCs and their effects on mineralization in human gingival fibroblasts (GF), which typically don't mineralize on their own.
- Results showed that ECM from both normal and osteogenic conditions allowed GF to attach and grow, with osteogenic ECM promoting greater mineralization, indicating potential applications for tissue engineering in bone-related therapies.
Aortic aneurysms (AAs) consist of slow proteolysis and loss of both collagen and elastin matrix in the aorta wall, leading to wall dilation, weakening and rupture in well-advanced lesions. This can occur in both abdominal aorta (Abdominal Aortic Aneurysm: AAA) and thoracic aorta (Thoracic Aortic Aneurysm: TAA). To date, no non-surgical therapy has been proposed to slow or stop AA progression.
View Article and Find Full Text PDFHuman gingival stem cells (HGSCs) can be easily isolated and manipulated in culture to investigate their multipotency. Osteogenic differentiation of bone-marrow-derived mesenchymal stem/stromal cells has been well documented. HGSCs derive from neural crests, however, and their differentiation capacity has not been fully established.
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- Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic disorder linked to the COL3A1 gene that can lead to various serious health issues, and its diagnosis is often challenging due to the scarcity of identifiable symptoms.
- A study conducted with 17 vEDS patients revealed a low prevalence of the traditionally recognized oral sign of gingival recession, while other oral problems like gingival fragility and dentin formation defects were noted as more significant symptoms.
- The findings suggest that relying solely on gingival recession for diagnosing vEDS is inadequate, and a new oral diagnostic score based on several identified oral features may provide a more accurate assessment.
Background: The modulation abilities of gingival fibroblasts open new therapeutic strategies for the treatment of vascular diseases (e.g., aneurism) and irradiation burns.
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