Publications by authors named "Francois Briat"
Human papillomavirus type 16 (HPV16) and other oncoviruses have been shown to block innate immune responses and to persist in the host. However, to avoid viral persistence, the immune response attempts to clear the infection. IL-1β is a powerful cytokine produced when viral motifs are sensed by innate receptors that are members of the inflammasome family.
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- The liver is the body's largest gland and plays a key role in the immune system through liver macrophages known as Kupffer cells (KC), which serve as the first defense against liver pathogens.
- Research has shown that KC can express genes for various inflammasome complexes and produce pro-inflammatory cytokines IL-1β and IL-18, which help activate other immune responses.
- Additionally, the study found that hepatitis B virus can inhibit the AIM2 inflammasome, impacting the immune response in the liver, indicating that understanding KC's function could lead to new treatments for chronic liver diseases.