Construct Validity and Responsiveness of the Pediatric Quality of Life Inventory 4.0 Generic Core Scales and Infant Scales in the PICU.

Objectives: To assess the construct validity and the responsiveness of the Pediatric Quality of Life Inventory 4.0 Generic Core Scales and Infant Scales in the medical-surgical (PICU) and cardiac PICU.

Design/setting/participants: Prospective cohort study of 367 inpatients admitted either to the PICU or the cardiac ICU at Seattle Children's Hospital from January 2012 to June 2013.

Health-related quality of life following pediatric critical illness.

Purpose: The aims of this focused review of the literature on children surviving critical illness were to (1) determine whether health-related quality of life (HRQL) represents a clinically meaningful outcome measure for children surviving critical illness and (2) evaluate the HRQL measures implemented in pediatric critical care studies to date.

Methods: This was a focused review of the literature from 1980 to 2015 based on a search of EMBASE/PubMed, MEDLINE and PsycInfo assessing trends and determinants of HRQL outcomes in children surviving critical illness. We also evaluated the psychometric properties of the HRQL instruments used in the studies identified by examining each measure's reported reliability, validity and sensitivity to clinical change.

Acute central nervous system complications in pediatric hematopoietic stem cell patients.

Acute neurologic complications in pediatric hematopoietic stem cell transplant (HSCT) patients cause significant morbidity and mortality. To conduct a comprehensive review of the existing literature reporting acute neurologic complications of the central nervous system among children undergoing HSCT. Comprehensive literature review from 2000 to 2014 using Medline.

Outcome of pediatric hematopoietic stem cell transplant recipients requiring mechanical ventilation.

Purpose: To assess the risk factors for intensive care unit admission among children receiving hematopoietic stem cell transplantation (HSCT) and to test the hypothesis that multiple organ failure (MOF) increases the odds of death among HSCT patients who receive mechanical ventilation (MV).

Methods: The chart of all consecutive HSCTs at Seattle Children's Hospital and pediatric HSCT patients admitted to the pediatric critical care unit of a tertiary care pediatric hospital from January 2000 to September 2006 were reviewed retrospectively.

Results: Charts of 266 HSCT patients were reviewed.

Emergence of oseltamivir-resistant pandemic H1N1 in an immunocompetent child with severe status asthmaticus.

Introduction: Pandemic influenza A (H1N1) may cause severe illness in pediatric patient with chronic lung disease.

Case Report: We describe the emergence of oseltamivir resistance in an immunocompetent child with status asthmaticus triggered by pandemic influenza A (H1N1). This case highlights the possible relationship between influenza viral load and risk of resistance emergence in children with asthma.

Lemierre syndrome in a 5-month-old male infant: Case report and review of the pediatric literature.

Objectives: To report, to the best of our knowledge, the youngest patient with Lemierre syndrome.

Design: Descriptive case report with review of the pediatric literature.

Setting: Pediatric intensive care unit in a tertiary referral hospital.