Publications by authors named "Franco F Roldan Gallardo"
Article Synopsis
- The study explores how dyslipidemia, specifically oxidized LDL (OxLDL), affects the proliferation of prostatic stromal cells and the release of extracellular vesicles (EVs), which are linked to Benign Prostatic Hyperplasia (BPH).
- Mice were given a high-fat diet and human prostatic stromal cells were exposed to OxLDL, revealing that dyslipidemic conditions promote increased cell growth and the secretion of EVs that further stimulate this growth.
- Treatment with metformin was found to significantly reduce OxLDL-induced cell proliferation, suggesting it could be a potential therapeutic option for managing BPH by targeting the underlying mechanisms associated with dyslipidemia.
The human prostate is an androgen-dependent gland where an imbalance in cell proliferation can lead to benign prostatic hyperplasia (BPH), which results in voiding lower urinary tract symptoms in the elderly. In the last decades, novel evidence has suggested that BPH might represent an element into the wide spectrum of disorders conforming the Metabolic Syndrome (MS). The dyslipidemic state and the other atherogenic factors of the MS have been shown to induce, maintain and/or aggravate the pathological growth of different organs, with data regarding the prostate being still limited.
View Article and Find Full Text PDFObjective: This study was designed to facilitate genetic studies that would allow information on population structure and genetic diversity of natural or captive stocks of paca (Cuniculus paca), a species of ecological and socioeconomic importance, by testing cross-amplification of 20 heterologous microsatellite primer pairs developed for guinea pigs (Cavia porcellus) and capybara (Hydrochoerus hydrochaeris).
Results: Those primers that showed the best amplification profile in blood samples were subsequently applied to scats and saliva samples, to evaluate their efficiency. Of the 13 microsatellite pairs that amplified in blood, one-third (32%) were successfully amplified in saliva and scat samples.