Prolonged diacetylmorphine take-home during the COVID-19 pandemic-Results of a retrospective cohort study.

Background And Aims: Legal regulations for dispensing in Swiss heroin-assisted treatment were relaxed during the COVID-19 pandemic, allowing prolonged take-home of up to 7 days instead of two to reduce patient contact and the risk of infection. Our study aimed to measure the consequences of this new practice.

Design, Setting And Participants: This was a retrospective cohort study set in Switzerland's largest outpatient centre for opioid agonist therapy.

Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder.

Objective: Bipolar disorder is a severe mental disorder associated with persistent sleep disturbances and elevated levels of mRNA coding for pro-inflammatory cytokines within peripheral monocytes. The mechanisms causing and sustaining a reduced sleep quality remain elusive. The pro-inflammatory cytokine receptor IL-6R is known to negatively affect sleep quality and architecture.