Publications by authors named "Francisco de la Cerda-Ojeda"
Background And Hypothesis: Young adults starting kidney replacement therapy (KRT) during childhood and reaching their 18th birthday (i.e. adult survivors of childhood KRT) form a challenging population of interest to nephrologists treating adults, as during this period there will be a transition to adult renal centres.
View Article and Find Full Text PDFArticle Synopsis
- X-linked hypophosphatemia (XLH) is a rare hereditary disease caused by mutations in the PHEX gene, leading to symptoms like rickets and growth retardation in children, but there is limited data on its clinical spectrum and treatment outcomes.
- A study of 48 Spanish patients revealed that common findings at diagnosis included bone deformities and significant growth issues, with no difference in severity based on gender and no correlation between gene mutations and clinical manifestations.
- Conventional treatments, such as phosphate and vitamin D supplementation, were ineffective at improving growth or correcting low phosphate levels over a median follow-up of 7.42 years.
Hypophosphataemic rickets (HR) is a group of rare disorders caused by excessive renal phosphate wasting in which the participation of fibroblast growth factor 23 (FGF23) can be prominent. These diseases pose therapeutic challenges with important consequences for growth and bone development in childhood, with higher risk of fractures and poorer bone healing, dental problems, and nephrolithiasis or nephrocalcinosis. In some cases, the diagnostic delay can be very long; laboratory findings and an exhaustive anamnesis could help distinguish between various pathologies, and FGF23 values-although currently not routinely measured-have implications for the differential diagnosis.
View Article and Find Full Text PDFPatients with chronic kidney disease in the hemodialysis program are exposed to large amounts of water, as this constitutes about 96% of the dialysis fluid. It is known that the use of better quality water decreases the state of chronic inflammation in dialysis patients. Disinfection as part of water treatment plays an important role in meeting the established quality standards; currently, heat disinfection is highly recommended, however its dose is not clearly established in the literature.
View Article and Find Full Text PDFObjective: To find out if cardiovascular alterations are present in pediatric patients with X-linked hypophosphatemia (XLH).
Study Design: Multicentre prospective clinical study on pediatric patients included in the RenalTube database ( www.renaltube.