Publications by authors named "Francisco X Castellanos-Juarez"

Article Synopsis
  • The study examines the complexity of teeth anatomy, especially focusing on C-shaped canals and radix entomolaris, which impact the effectiveness of root canal treatments.
  • Using cone-beam computed tomography (CBCT), researchers identified the prevalence and types of these anatomical variations in a sample of 2173 teeth from a Mexican population.
  • Results showed that C-shaped canals were more common in second mandibular molars, with a significant gender difference in prevalence, highlighting the importance of understanding these variations for improving endodontic treatment success rates.
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Article Synopsis
  • Parkinson's disease (PD) is a neurodegenerative disorder associated with abnormal protein clumping and faulty protein regulation, prompting this study to analyze gene expression in a Mexican-Mestizo PD group compared to healthy individuals.
  • The research involved 87 PD patients and 87 controls, revealing significant downregulation of specific genes in the PD group, which correlates with the disease's presence.
  • A newly developed gene expression model based on these findings shows potential for accurately diagnosing early-stage PD, highlighting a notable connection between reduced gene expression and the condition in the studied population.
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Background: Among the Toll-like receptors (TLR) that are dependent of myeloid response protein (MyD88), the TLR4 and TLR2 are directly associated with low-grade chronic inflammation; however, they are not been investigated in subjects with metabolically healthy obesity (MHO). Thus, the objective of this study was to determine the association between the expression of TLR4, TLR2, and MyD88 with low-grade chronic inflammation in individuals with MHO.

Methods And Results: Men and women with obesity aged 20 to 55 years were enrolled in a cross-sectional study.

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Clinical criteria diagnose Parkinson's disease (PD), therefore, it is crucial to find biological elements that could support diagnosis or even act as prognostic tools of PD. The SNCA gene codifies a protein called α - synuclein; several studies associate genetic and biochemical factors of SNCA with PD, including transcript and plasmatic protein levels, however, contradictory evidence indicates inconclusive results. We aim to compare SNCA mRNA expression, plasmatic α-syn protein and rs356219 SNP between PD cases and a control group, and to identify a potential biomarker in Mexican mestizos', focusing on these three components determined in blood.

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Objective: To determine the seroprevalence of immunoglobulin (Ig)G and IgM antibodies and its association with the characteristics of the study population from the northern Mexican city of Durango, Mexico.

Methods: Through a cross-sectional study design, inhabitants of Durango City, Mexico were surveyed between June 2018 and November 2018. Serum samples from the subjects were analysed for anti- IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays.

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Objectives: This study aimed to determine the seroprevalence of () infection in pregnant women in Matehuala City, Mexico; and the associated risk factors.

Design: A cross-sectional study.

Setting: Matehuala City, Mexico.

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The link between Toxoplasma gondii infection and multiple sclerosis remains controversial. In the present study, we aimed to determine the association between T. gondii seropositivity and multiple sclerosis.

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Parkinson's disease (PD) is the second most common movement disorder. Genetic risk factors provide information about the pathophysiology of PD that could potentially be used as biomarkers. The gene encodes for the aldehyde dehydrogenase enzyme, which is involved in the disposal of toxic metabolites of dopamine.

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Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and postural instability as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor for PD. Despite those findings, some studies have suggested that the association may be ethnically dependent.

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Background: Depressive disorders are common during pregnancy. There is compelling evidence that the inflammatory response system is important in the pathophysiology of depression. Higher concentrations of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-α) in depressed subjects have been described.

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Blood lead levels (BLLs) and delta-aminolevulinic acid dehydratase (ALAD) activity are considered biomarkers of lead exposure and lead toxicity, respectively. The present study was designed to investigate the association between BLLs and ALAD activity in pregnant women from Durango, Mexico. A total of 633 pregnant women aged 13-43 years participated in this study.

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Objectives: To determine the association between infection and Parkinson's disease and to investigate whether seropositivity is associated with the general characteristics of patients with Parkinson's disease.

Design: Case-control study.

Setting: Cases and controls were enrolled in Durango City, Mexico.

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Background: Pregnant women exposed to lead are at risk of suffering reproductive damages, such as miscarriage, preeclampsia, premature delivery and low birth weight. Despite that the workplace offers the greatest potential for lead exposure, there is relatively little information about occupational exposure to lead during pregnancy. This study aims to assess the association between blood lead levels and occupational exposure in pregnant women from Durango, Mexico.

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Background: Exposure to arsenic in drinking water has been associated with various complications of pregnancy including fetal loss, low birth weight, anemia, gestational diabetes and spontaneous abortion. However, to date, there are no studies evaluating its possible association with preeclampsia.

Methods: This case-control study involved 104 preeclamptic and 202 healthy pregnant women.

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Several studies have revealed a negative association between blood lead levels and hematological impairment. In this cross-sectional study, we examined the relationship between blood lead levels and hematological indices in 292 pregnant women from Durango, Mexico. Apparently healthy pregnant women, aged 14-41 years and at 3-41 weeks of gestation, were recruited between June 2007 and May 2008.

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Variations in genes involved in DNA repair systems have been proposed as risk factors for the development of preeclampsia (PE). We conducted a case-control study to investigate the association of Human apurinic/apyrimidinic (AP) endonuclease (APEX1) Asp148Glu (rs1130409), Xeroderma Pigmentosum group D (XPD) Lys751Gln (rs13181), X-ray repair cross-complementing group 1 (XRCC) Arg399Gln (rs25487) and X-ray repair cross-complementing group 3 (XRCC3) Thr241Met (rs861539) polymorphisms with PE in a Mexican population. Samples of 202 cases and 350 controls were genotyped using RTPCR.

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Objective: To investigate the relationship between COMT G675A and MTHFR C677T polymorphisms and hypertension disorders of pregnancy (HDP) in a Mexican mestizo population.

Design And Methods: This case-control study involved 194 HDP and 194 normoevolutive pregnant women. The polymorphisms were genotyped by real time PCR.

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Background: Oxidative stress has been associated with several complex diseases. Effects generated as a result of oxidative stress may be modulated by various genes. Variation in these genes, particularly when located within coding or regulating regions, may be the primary cause of this modulation.

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Northern-blot analysis revealed that cel9 and cel48, which encode family 9 and 48 glycosyl hydrolases, respectively, were expressed as a bicistronic mRNA in the soil bacterium Myxobacter sp. AL-1. The two cistrons of the cel9-cel48 mRNA as well as their encoded products were detected in stationary phase cultures of Myxobacter sp.

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ytkD and mutT of Bacillus subtilis encode potential 8-oxo-dGTPases that can prevent the mutagenic effects of 8-oxo-dGTP. Loss of YtkD but not of MutT increased the spontaneous mutation frequency of growing cells. However, cells lacking both YtkD and MutT had a higher spontaneous mutation frequency than cells lacking YtkD.

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The regulation of expression of ytkD, a gene that encodes the first functional antimutator 8-oxo-dGTPase activity of B. subtilis, was studied here. A ytkD-lacZ fusion integrated into the ytkD locus of wild-type B.

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