Publications by authors named "Francisco Verdejo"
Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.
Int J Mol Sci
May 2023
Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promoting resistance to treatments. To date no studies have determined the impact of genetic variation in autophagy-related genes on MM risk.
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- - The study aims to assess how different intensities of supervised exercise, along with lifestyle counseling, can effectively manage metabolic syndrome risk factors in low-active adults aged 30-55 over 40 weeks.
- - Participants will be divided into three groups: one receiving aerobic interval training, another undergoing low-to-moderate continuous training, and a control group receiving counseling only.
- - The outcomes measured include various metabolic risk factors, physical fitness, and lifestyle changes, as well as an evaluation of the economic cost-effectiveness of the program.
Background: The early identification of influenza outbreaks has became a priority in public health practice. A large variety of statistical algorithms for the automated monitoring of influenza surveillance have been proposed, but most of them require not only a lot of computational effort but also operation of sometimes not-so-friendly software.
Results: In this paper, we introduce FluDetWeb, an implementation of a prospective influenza surveillance methodology based on a client-server architecture with a thin (web-based) client application design.