A national study of health care service utilization and substance use after the 2010 Chilean earthquake.

Objective: A national epidemiological survey in Chile assessed adaptive (health care utilization) and maladaptive (substance use) postearthquake behaviors.

Methods: Three months after the 8.8-magnitude 2010 Bio-Bio earthquake, face-to-face interviews were conducted with a representative sample of 2,108 adults.

Exposure to rapid succession disasters: a study of residents at the epicenter of the Chilean Bío Bío earthquake.

We examined cumulative and specific types of trauma exposure as predictors of distress and impairment following a multifaceted community disaster. Approximately 3 months after the 8.8 magnitude earthquake, tsunami, and subsequent looting in Bío Bío, Chile, face-to-face interviews were conducted in 5 provinces closest to the epicenter.

Influence of cocaine self-administration on learning related to prefrontal cortex or hippocampus functioning in rats.

Rationale: Individuals who abuse cocaine have cognitive deficits, particularly in functions associated with the orbitofrontal cortex. It is not clear to what extent the impact of cocaine on cognitive functioning is related to its role as a behavioral reinforcer. A preclinical means to investigate this issue is to use a yoked-triad procedure in which sets of three animals either contingently self-administer cocaine or receive passive administration of cocaine or saline in a noncontingent manner.

Effects of persistent cocaine self-administration on amygdala-dependent and dorsal striatum-dependent learning in rats.

Rationale: The influence of persistent cocaine self-administration on learning and memory has never been evaluated.

Objectives: Our objective was to isolate the effects of contingently administered cocaine from those of its general pharmacological or non-contingent actions on multiple memory system functioning.

Methods: A triad design was used to yoke passive cocaine and saline administration to the behavior of rats who were actively self-administering cocaine.

Comparison of the Efficacy and Tolerability of Dexketoprofen and Ketoprofen in the Treatment of Primary Dysmenorrhea.

Dexketoprofen, the pure S(+)-enantiomer of ketoprofen, is a promising new analgesic, but few clinical trials have yet examined its efficacy and tolerability. In this study, patients with a history of primary dysmenorrhea were treated with dexketoprofen doses of 12.5 and 25 mg, ketoprofen 50 mg, and placebo using a randomized, four-way crossover design.