Novel Approaches in the Systemic Management of High-Risk Prostate Cancer.

Locally advanced prostate cancer comprises approximately 20% of new prostate cancer diagnoses. For these patients, international guidelines recommend treatment with radiotherapy (RT) to the prostate in combination with long-term (2-3 years) androgen deprivation therapy (ADT), or radical prostatectomy in combination with extended pelvic lymph node dissection (PLND) as another treatment option for selected patients as part of multimodal therapy. Improvements in overall survival with docetaxel or an androgen receptor signaling inhibitor have been achieved in patients with metastatic castration sensitive or castration resistant prostate cancer.

COVID-19 cases, hospitalizations, outpatients, and deaths in Mexico by ethnicity and state-level income.

Introduction: Mexico is one of the countries that is most affected by mortality due to COVID-19. Once infected, the indigenous population living in the lower-income states had worse outcomes. Our objectives were to analyze outcomes by ethnic group, and determine the association between state-level income and the incidence, hospitalizations, outpatients, and death rates per 100,000 population.

[Epidemiology of COVID-19 in Mexico: from the 27th of February to the 30th of April 2020].

Background: The first case of COVID-19 detected in Mexico was on the 27 of February 2020. On the 30 of April, 64 days after this first diagnosis, the number of patients had increased exponentially, reaching 19 224 confirmed cases and 1859 (9.67%) deaths.

Epidemiology of COVID-19 in Mexico: from the 27th of February to the 30th of April 2020.

Background: The first case of COVID-19 detected in Mexico was on the 27 of February 2020. On the 30 of April, 64 days after this first diagnosis, the number of patients had increased exponentially, reaching 19 224 confirmed cases and 1859 (9.67%) deaths.

Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity.

DNA strand breaks trigger marked phosphorylation of histone H2AX (i.e. gamma-H2AX).