Induction of New Aromatic Polyketides from the Marine Actinobacterium through an OSMAC Approach.

Using the OSMAC (One Strain Many Compounds) approach, the actinobacterium , derived from an unidentified cnidarian collected from a reef near Pointe de Bellevue in Réunion Island (France), was subjected to cultivation under diverse conditions. This endeavour yielded the isolation of a repertoire of 23 secondary metabolites (-), wherein five compounds were unprecedented as natural products (-). Specifically, compounds and showcased novel anthrone backbones, while compound displayed a distinctive tetralone structure.