Publications by authors named "Francisco Redelico"

Purpose: This study aims to describe the total EEG energy during episodes of intracranial hypertension (IH) and evaluate its potential as a classification feature for IH.

New Methods: We computed the sample correlation coefficient between intracranial pressure (ICP) and the total EEG energy. Additionally, a generalized additive model was employed to assess the relationship between arterial blood pressure (ABP), total EEG energy, and the odds of IH.

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Article Synopsis
  • This study investigates the potential of using electroencephalography (EEG) to create a real-time, noninvasive way to measure intracranial pressure (ICP) as opposed to traditional invasive methods.* -
  • Researchers conducted experiments on a porcine model of intracranial hypertension, analyzing the relationship between ICP and the slope of the EEG power spectral density, quantified by the ϕ angle.* -
  • Results show a strong correlation between the ϕ angle and ICP levels, suggesting that EEG ϕ angle could be a reliable indicator for monitoring ICP and cerebral perfusion in real time.*
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Intracranial pressure (ICP) monitoring is commonly used in the follow-up of patients in intensive care units, but only a small part of the information available in the ICP time series is exploited. One of the most important features to guide patient follow-up and treatment is intracranial compliance. We propose using permutation entropy (PE) as a method to extract non-obvious information from the ICP curve.

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Background: Intracranial hypertension (HI) is associated with worse neurological outcomes and higher mortality. Although there are several experimental models of HI, in this article we present a reproducible, reversible, and reliable model of intracranial hypertension, with continuous multimodal monitoring.

New Method: A reversible intracranial hypertension model in swine with multimodal monitoring including intracranial pressure, arterial blood pressure, heart rate variation, brain tissue oxygenation, and electroencephalogram is developed to understand the relationship of ICP and EEG.

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Background: To detect an early increase in the inflammatory response might prove to be vital for mitigating the deleterious effects of the disease over time.

Cases: A 52-year-old obese man with moderate asthma and hypertension, who developed COVID-19 and had moderate symptoms, used a wearable device to record heart rate variability (HRV) during his illness. He had low parasympathetic tone, which decreased daily until it reached almost 2 standard deviations (SD) below normal values at the end of the second week.

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In the present work, an ischaemic process, mainly focused on the reperfusion stage, is studied using the informational causal entropy-complexity plane. Ischaemic wall behavior under this condition was analyzed through wall thickness and ventricular pressure variations, acquired during an obstructive flow maneuver performed on left coronary arteries of surgically instrumented animals. Basically, the induction of ischaemia depends on the temporary occlusion of left circumflex coronary artery (which supplies blood to the posterior left ventricular wall) that lasts for a few seconds.

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The Big Data paradigm can be applied in intensive care unit, in order to improve the treatment of the patients, with the aim of customized decisions. This poster is about the infrastructure necessary to built a Big Data system for the ICU. Together with the infrastructure, the conformation of a multidisciplinary team is essential to develop Big Data to use in critical care medicine.

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Intensive care represents the critical care setting of a hospital, where fundamental, precise, and fast decisions have to be made. These decisions will affect the outcome of the patients in a matter of few hours. The knowledge of the therapeutic interventions applied in this setting is evolving, thus the perspective of Big Data may provide a new paradigm in the ICU.

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