[Relevance of CYP2C19 2 regarding platelet reactivity in patients with acute coronary syndrome treated with clopidogrel].

Background And Objective: Previous studies have shown that the metabolism of P2Y12 receptor blockers is influenced not only by CYP2C19 2 but also by PON1-Q192R alelles. We aimed to evaluate the impact of CYP2C19 2 and PON1-Q192R polymorphisms carriage in platelet reactivity and clinical outcome in patients with ischemic heart disease undergoing cardiac catheterization.

Patients And Method: We recruited prospectively patients with acute coronary syndrome undergoing cardiac catheterization (n=247).

Homeostatic control of polyamine levels under long-term salt stress in Arabidopsis: changes in putrescine content do not alleviate ionic toxicity.

Salt stress has been frequently studied in its first osmotic phase. Very often, data regarding the second ionic phase is missing. It has also been suggested that Putrescine or/and Spermine could be responsible for salt resistance.

The EXTREME registry: titanium-nitride-oxide coated stents in small coronary arteries.

Objectives: We sought to explore the immediate results of Titan2 stent implantation in small coronary arteries, as well as the incidence of major adverse cardiac events (MACE) at six months follow-up.

Background: The safety of Titan2 stent has been confirmed in several studies in real-life unselected populations.

Methods: We enrolled 311 consecutive patients admitted for percutaneous intervention for at least one significant (50%) de novo lesion in a native small coronary artery (2.

Heart-hand syndrome.

Heart-hand syndromes show substantial clinical and genetic heterogeneity. The unusual case of a patient with a heart-hand syndrome consisting of preaxial polydactylia, postaxial syndactylia, parachute mitral valve, mild subaortic stenosis, and double outlet right ventricle is presented and discussed. The importance of distinguishing Holt-Oram syndrome from its phenocopies and other heart-hand syndromes is underlined.

[Treatment of acute myocardial infarction by primary angioplasty on-site compared with treatment following interhospital transfer: short- and long-time clinical outcomes].

Introduction And Objectives: Primary angioplasty is the treatment of first choice for patients with ST-segment elevation acute myocardial infarction. However, its use is limited as the majority of patients present at hospitals without a catheterization laboratory. The objective of this study was to determine short- and long-term outcomes of systematically implementing a primary angioplasty program at two hospitals, one of which did not have a catheterization laboratory.

[Comparison between theoretical an actual intracoronary stent dimensions in non-complex lesions].

The minimum in-stent lumen diameter is a predictor of restenosis. Stent dimensions provided by manufacturers are derived from in vitro tests. The aim of this study was to compare actual stent dimensions obtained by angiography and intracoronary ultrasound with dimensions that would be expected theoretically for a given inflation pressure in a cohort of 100 non-complex lesions suitable for direct stenting.

[Short- and medium-term outcomes of percutaneous coronary intervention for unprotected left main coronary artery disease in patients who are poor candidates for surgical revascularization].

Introduction And Objectives: Surgical revascularization is the procedure of choice for unprotected left main coronary artery stenosis, but it may be unsuitable in some patients. We report short- and medium-term outcomes of percutaneous coronary intervention for unprotected left main coronary artery stenosis in a series of patients who were poor candidates for surgery.

Patients And Method: Descriptive study of a historic cohort of consecutive patients with unprotected left main coronary artery stenosis who were not candidates for surgery, treated with percutaneous coronary intervention at a single center between April 1999 and December 2003.

Utility of the fractional flow reserve in the evaluation of angiographically moderate in-stent restenosis.

Aims: The evaluation of in-stent restenosis (ISR) is usually based on angiographic quantification. This evaluation is sometimes difficult and it has not an accurate clinical correlation. Fractional flow reserve (FFR) measured by intracoronary pressure wire has demonstrated its value in determining the functional repercussion of coronary stenosis.

[Comparison of intracoronary ultrasound expansion parameters in coronary stents implanted with or without balloon predilatation. A randomized intravascular ultrasound study].

Introduction And Objectives: Coronary stenting without balloon predilatation is a safe technique associated with similar clinical results and lower costs, use of contrast and exposure to radiation in comparison to stenting with predilatation. After direct stenting, expansion may be reduced if the stenotic lesion was not predilatated. This study compared a).

[Direct stenting without predilatation: influence of stent diameter on the immediate results].

The influence of stent diameter in a direct stenting technique was analyzed. We retrospectively identified 987 consecutive lesions in 773 patients in whom direct stenting was attempted. Lesions were divided into two groups: group 1, nominal stent diameter 2.

[Angiographic results of thrombectomy performed with two new devices in lesions with intracoronary thrombus].

Introduction And Objective: The presence of intracoronary thrombus is associated with less favorable results of percutaneous coronary interventions. In recent years, new devices have been designed to improve the outcome of these procedures when an intracoronary thrombus is present. The results of two new systems of thrombectomy used in a single center are analyzed.

[Time intervals in primary angioplasty from onset of symptoms until restoration of blood flow].

Introduction And Objective: A limitation to the widespread use of primary angioplasty is delayed reperfusion. Most current data are from clinical trials and there is little information about the use of primary angioplasty in clinical practice. The objective of this study was to analyze the duration of each stage leading to primary angioplasty in a hospital where it is the treatment of choice for acute myocardial infarction.

[Program of coronary angioplasty in acute myocardial infarction in the region of Murcia (Spain). APRIMUR Registry].

Introduction And Objectives: The geographic characteristic and healthcare facilities of the region of Murcia, Spain, are enough to assure that coronary angioplasty can be carried out in acute myocardial infarction according to current guidelines. The development of a regional program for coronary intervention in acute myocardial infarction may increase the number of patients who would benefit from reperfusion therapy in general and primary angioplasty in particular.

Material And Methods: The program was initiated in April 2000 and had four steps: 1) Establishment of primary angioplasty as the treatment of choice of acute myocardial infarction in the regional reference hospital.

[Direct Stenting without Predilation: a Single-Center Experience with 1,000 Lesions].

Introduction: Direct stenting has been shown to save costs, procedural time, radiation, and contrast use. We analyze the results of direct stenting in daily practice.

Material And Methods: We retrospectively analyzed the interventions in the first 1,000 lesions that were treated with direct stenting at our center.

[Long-term prognosis of patients with myocardial bridge and angiographic milking of the left anterior descending coronary artery].

Introduction: Myocardial bridging with systolic compression (milking) of the left anterior descending coronary artery may be associated with myocardial ischemia. Little information is available about the long-term prognosis of patients with this coronary anomaly.

Material And Methods: A review was made of coronary angiographies of patients diagnosed as ischemic heart disease made between 1994 and 1999 in two centers.

[Clinical utilization of the coronary pressure wire].

Introduction: Earlier studies have established the value of coronary pressure wires for diagnosing and monitoring the treatment of patients with coronary artery disease. In this study we demonstrated their usefulness in the daily clinical practice of a catheterization laboratory.

Material And Methods: A retrospective study of the use of pressure wires in our laboratory between October 1998 and November 2000.