Gene therapy for diabetic foot ulcers: Interim analysis of a randomised, placebo-controlled phase 3 study of VM202 (ENGENSIS), a plasmid DNA expressing two isoforms of human hepatocyte growth factor.

To evaluate the status of a 7-month phase 3 study conducted to test the effect of intramuscular injections of VM202 (ENGENSIS), a plasmid DNA encoding human hepatocyte growth factor, into the calf muscles of chronic nonhealing diabetic foot ulcers with concomitant peripheral artery disease. The phase 3 study, originally aimed to recruit 300 subjects, was discontinued because of slow patient recruitment. An unprespecified interim analysis was performed for the 44 subjects enrolled to assess the status and determine the future direction.

Crop Classification in Satellite Images through Probabilistic Segmentation Based on Multiple Sources.

Classification methods based on Gaussian Markov Measure Field Models and other probabilistic approaches have to face the problem of construction of the likelihood. Typically, in these methods, the likelihood is computed from 1D or 3D histograms. However, when the number of information sources grows, as in the case of satellite images, the histogram construction becomes more difficult due to the high dimensionality of the feature space.